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目的血清纤维蛋白原(Fib)、炎性介质及肿瘤标志物检测在结直肠癌中的诊断价值。方法检测结直肠癌患者85例(观察组)和结直肠良性病变患者75例(对照组)血清Fib、血清淀粉样蛋白A(SAA)、C反应蛋白(CRP)、癌胚抗原(CEA)和糖蛋白抗原19-9(CA19-9),分析其临床诊断价值。结果观察组血清Fib、SAA、CRP、CEA和CA19-9水平均高于对照组[(4.21±0.77)g/L vs.(3.31±0.67)g/L、(15.63±2.36)μg/ml vs.(6.98±1.53)μg/ml、(5.32±1.39)mg/L vs.(2.89±0.94)mg/L、(47.30±7.95)ng/ml vs.(17.85±4.86)ng/ml和(101.24±10.86)U/ml vs.(18.32±4.55)U/ml](P<0.01)。联合检测的灵敏度和准确度均高于单项指标检测(P<0.01)。结论血清Fib、炎性介质及肿瘤标志物的联合检测可有效提高结直肠癌诊断的灵敏度和准确度。
Objective To investigate the diagnostic value of serum fibrinogen (Fib), inflammatory mediators and tumor markers in colorectal cancer. Methods Serum levels of Fib, serum amyloid A (SAA), C-reactive protein (CRP), carcinoembryonic antigen (CEA) and serum fibronectin in 85 patients with colorectal cancer (observation group) and 75 patients with colorectal benign disease (control group) Glycoprotein antigen 19-9 (CA19-9), analysis of its clinical diagnostic value. Results The levels of Fib, SAA, CRP, CEA and CA19-9 in the observation group were significantly higher than those in the control group [(4.21 ± 0.77) g / L vs. (3.31 ± 0.67) g / L vs (6.98 ± 1.53) μg / ml, (5.32 ± 1.39) mg / L vs. (2.89 ± 0.94) mg / L, (47.30 ± 7.95) ng / ml vs. (17.85 ± 4.86) ng / ml and ± 10.86 U / ml vs. (18.32 ± 4.55) U / ml] (P <0.01). The sensitivity and accuracy of the combined detection were higher than the single index test (P <0.01). Conclusion The combination of serum Fib, inflammatory mediators and tumor markers can effectively improve the sensitivity and accuracy of colorectal cancer diagnosis.