有关血型糖蛋白C(GPC)的研究,近年来进展很快。它的糖蛋白一级结构及基因结构均已阐明,主要组成 Gerbich血型抗原系统。GPD(或 rGP)是从GPC的 N末端区截短而成。通过 GPC外显子2、3、4的单个或多个缺失,可产生若干表型的GPC变种。GPC参与红细胞膜骨架的构建,在维持红细胞的正常形态和膜机械特性中发挥重要作用。它还可能与恶性疟魔虫入侵红细胞有关。本文就Ge血型抗原,GPC的分子结构和功能等三方面概况作一综述。 Research on glycophorin C (GPC) has progressed rapidly in recent years. Its glycoprotein primary structure and gene structure have been elucidated, the main composition of the Gerbich blood group antigen system. The GPD (or rGP) is truncated from the N-terminal region of the GPC. Several GPC variants of several phenotypes can be generated by single or multiple deletions of GPC exons 2, 3, GPC involved in the construction of erythrocyte membrane scaffold plays an important role in maintaining the normal morphology and membrane mechanical properties of erythrocytes. It may also be associated with invasion of erythrocytes by P. falciparum. This article reviews the three aspects of Ge blood group antigen, GPC molecular structure and function.