分别将催化计量和化学计量的(1R,2S)或(1S,2R)-2-氨基-1,2-二本基乙醇衍生的手性氨基醇配体1应用于催化不对称Reformatsky反应,研究了手性配体的结构及其用量与反应对映选择性的关系,溶剂和底物的改变对e.e.值的影响;并设计与研究了双手性体系,使该反应在催化量(25mol%)手性配体的作用下,得到中等对映选择性;另外,还比较了不同的实验方法对反应的对映选择性的影响,提出了手性催化循环机理和反应过渡态模型,能较好地解释一系列实验事实. The catalytic and stoichiometric measurement of (1R, 2S) or (1S, 2R) -2-amino-1,2-dihydrobenzyl alcohol-derived chiral aminoalcohol ligand 1 was applied to the catalytic asymmetric Reformatsky reaction, The relationship between the structure and amount of the chiral ligand and the reaction enantioselectivity, the change of the solvent and the substrate on the ee value were also investigated. The chiral system was designed and studied, In addition, we also compare the influence of different experimental methods on the enantioselectivity of the reaction, proposed a chiral catalytic cycle mechanism and reaction transition state model, which can be better Explain a series of experimental facts.