论文部分内容阅读
氨茶碱有直接舒张支气管平滑肌的作用,从而缓解或解除支气管哮喘,疗效确切,是目前临床最常用的平喘药物之一。但氨茶碱有效治疗浓度较小(5～20μg/ml),个体差异大,当血药浓度低时,不能有效缓解哮喘,血药浓度过高时又可出现心律失常、抽搐等严重毒性反应。因此对哮喘患者给药个体化、最佳化,开展氨茶碱血药浓度监测工作势在必行。
Aminophylline has a direct relaxation of the role of bronchial smooth muscle, thereby relieving or relieving bronchial asthma, curative effect is one of the most commonly used clinically antiasthmatic drugs. However, the effective concentration of aminophylline treatment of small (5 ~ 20μg / ml), individual differences, when the plasma concentration is low, can not effectively alleviate asthma, blood concentration can occur when the arrhythmia, convulsions and other serious toxic reactions . Therefore, individualized administration of asthma patients, optimization, to carry out monitoring of aminophylline plasma concentration is imperative.