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目的观察探讨在上消化道出血病患中应用奥美拉唑的治疗效果及安全性。方法将江西省上饶县中医院消化内科门诊2015年1月—2016年5月收治的85例上消化道出血依次进行编号后利用随机数字表分为试验组(n=43)和对照组(n=42)。试验组患者在常规治疗的基础上联合应用奥美拉唑,对照组患者单纯给予常规治疗。统计并对比临床症状改善时间及止血时间,评估治疗效果、总有效率和死亡率,并将不良反应发生情况作为安全性的评估指标,对比不良反应发生率。结果试验组患者便血缓解时间、呕血改善时间、体征恢复正常时间及止血时间短于对照组(P<0.05)。试验组患者临床疗效优于对照组(P<0.05)。两组患者不良反应发生率、死亡率比较,差异无统计学意义(P<0.05)。结论采用奥美拉唑治疗上消化道出血的临床疗效确切,可有效改善患者的临床症状及体征,快速止血,且安全性高。
Objective To investigate the therapeutic effect and safety of omeprazole in patients with upper gastrointestinal bleeding. Methods 85 cases of upper gastrointestinal bleeding admitted from January 2015 to May 2016 in Shangrao Chinese Medicine Hospital of Jiangxi Province were sequentially numbered and randomly divided into experimental group (n = 43) and control group (n = = 42). Patients in the experimental group were treated with omeprazole on the basis of routine treatment, and those in the control group were given routine treatment. Statistics and comparison of clinical symptoms to improve the time and stop bleeding time, evaluation of the treatment effect, the total efficiency and mortality, and the occurrence of adverse reactions as a safety assessment index, compared with the incidence of adverse reactions. Results The patients in trial group had shorter time of hematochezia, improvement of hematemesis, shorter time to normal signs of recovery and shorter bleeding time than those in control group (P <0.05). The clinical efficacy of the experimental group was better than that of the control group (P <0.05). There was no significant difference between the two groups in the incidence of adverse reactions and mortality (P <0.05). Conclusion Omeprazole treatment of upper gastrointestinal bleeding clinical efficacy is exact, can effectively improve the patient’s clinical symptoms and signs, rapid hemostasis, and high safety.