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研究癌基因蛋白ｂｃｌ－２和ｐ５３与甲状腺肿瘤生物学行为的关系，探讨其在预后评估中的意义。方法：采用免疫组织化学ＳＡＢＣ法检测５０例甲状腺肿瘤中ｂｃｌ－２和ｐ５３蛋白的表达。结果：ｂｃｌ－２蛋白在甲状腺腺瘤及甲状腺癌的阳性表达率分别为９３．３％和６５．７％；ｐ５３蛋白在甲状腺腺瘤不表达，在甲状腺癌的阳性表达率为５１．４％．ｂｃｌ－２和ｐ５３蛋白在甲状腺癌的表达与病理类型无关；高分化及无淋巴结转移甲状腺癌中ｂｃｌ－２蛋白阳性表达率较高，而ｐ５３蛋白在低分化及伴淋巴结转移的甲状腺癌中阳性表达率高；ｂｃｌ－２与ｐ５３蛋白表达呈负相关。结论：ｂｃｌ－２和ｐ５３蛋白参与甲状腺肿瘤的发生与分化，且其表达水平的不同有助于预后评估。
To study the relationship between oncogene proteins bcl-2 and p53 and biological behavior of thyroid tumors, and to explore its significance in the evaluation of prognosis. Methods: Immunohistochemistry SABC method was used to detect the expression of bcl-2 and p53 protein in 50 cases of thyroid tumors. Results: The positive rates of bcl-2 protein in thyroid adenoma and thyroid carcinoma were 93.3% and 65.7%, respectively; p53 protein was not expressed in thyroid adenoma, and the positive rate in thyroid carcinoma was 51.4%. . The expression of bcl-2 and p53 protein in thyroid cancer has nothing to do with the pathological type; the positive rate of bcl-2 protein in highly differentiated and no lymph node metastasis thyroid carcinoma is high, but p53 protein is positive in poorly differentiated and lymphatic metastasis of thyroid carcinoma. The expression rate was high; bcl-2 was negatively correlated with the expression of p53 protein. CONCLUSIONS: bcl-2 and p53 proteins are involved in the occurrence and differentiation of thyroid tumors, and their different expression levels contribute to the prognosis.