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采用抗牛乳头瘤病毒（ＢＰＶ），癌胚抗原（ＣＥＡ）免疫组化技术及核仁组成区相关蛋白（ＡｇＮＯＲｓ）银染方法对１０１例尖锐湿疣（ＣＡ）和１２例宫颈鳞癌进行病理观察。结果ＣＡ的ＢＰＶ表达明显高于宫颈鳞癌；ＣＡ的ＣＥＡ阳性表达与宫颈鳞癌有显著性差异，而ＣＡ的不典型增生型其ＣＥＡ表达（弱阳性）与宫颈鳞癌则无显著性差异；ＣＡ的ＡｇＮＯＲｓ计数分布除不典型增生型外，其余各组与宫颈鳞癌有显著性差异。提示ＣＡ大多数为良性增生性病变，而不典型增生型有恶性发展的倾向．
101 cases of condyloma acuminatum (CA) and 12 cases of squamous cell carcinoma of cervix were observed by immunohistochemistry and anti-bovine papillomavirus (BPV), carcinoembryonic antigen (CEA) immunohistochemistry and silver staining of AgNORs . Results The expression of BPV in CA was significantly higher than that in cervical squamous cell carcinoma. The positive expression of CEA in CA was significantly different from that in cervical squamous cell carcinoma. However, the expression of CEA (weakly positive) in CA atypical hyperplasia was not significantly different from that in cervical squamous cell carcinoma. CA AgNORs count distribution except atypical hyperplasia, the remaining groups and cervical squamous cell carcinoma have significant differences. Tip CA most benign proliferative lesions, and atypical hyperplasia have a tendency to malignant development.