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目的分析社区住院尿路感染患者尿培养中产超广谱β-内酰胺酶(ESBLs)大肠埃希菌的检出情况及其相关危险因素。方法回顾性分析中段尿培养为大肠埃希菌的169例社区住院尿路感染患者的临床资料,进行ESBLs检测,用logistic回归分析产ESBLs大肠埃希菌致社区住院患者尿路感染的危险因素。结果单因素分析结果显示,ESBLs组和非ESBLs组的前列腺增生、住院天数、留置导尿、应用第三代头孢菌素等情况差异均有统计学意义(P值均<0.05)。logistic回归分析结果显示,留置导尿(OR=4.546)、应用第三代头孢菌素(OR=4.361)是产ESBLs大肠埃希菌致社区住院患者尿路感染的危险因素。结论留置导尿、应用第三代头孢菌素的社区住院患者更容易发生产ESBLs大肠埃希菌引起的尿路感染,应对存在上述危险因素的患者重点关注,严格掌握留置导尿指征和合理应用第三代头孢菌素,以减少社区住院患者产ESBLs大肠埃希菌尿路感染的发生。
Objective To analyze the detection of Escherichia coli (ESBLs) producing Escherichia coli and its related risk factors in urinary culture in community hospitalized patients with urinary tract infection. Methods The clinical data of 169 community urinary tract infection patients with urinary tract culture of Escherichia coli in the middle stage were retrospectively analyzed. The ESBLs were detected. Logistic regression was used to analyze the risk factors of urinary tract infection in community hospitalized patients with ESBLs-producing Escherichia coli. Results The results of univariate analysis showed that there were significant differences in benign prostatic hyperplasia, hospitalization days, indwelling catheterization and third generation cephalosporins between ESBLs group and non-ESBLs group (all P <0.05). Logistic regression analysis showed that the catheterization of urinary tract (OR = 4.546) and the third generation cephalosporin (OR = 4.361) were risk factors for urinary tract infection in community hospitalized patients with ESBLs-producing Escherichia coli. Conclusion Indwelling catheterization and community-based third-generation cephalosporins patients are more likely to develop urinary tract infections caused by Escherichia coli producing ESBLs. Patients with the above-mentioned risk factors should be given priority attention and strict indications of indwelling catheterization are reasonable The third generation of cephalosporins was applied to reduce the incidence of urinary tract infection with ESBLs-producing Escherichia coli in community hospitalized patients.