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目的探讨冠心病患者血管内皮依赖性舒张功能及血清一氧化氮浓度的变化情况,观察卡维地洛对其影响。方法用高分辨超声技术检测各组对象的肱动脉内皮依赖性舒张功能,硝酸还原酶法测定血清一氧化氮浓度。药物干预8周后复测上述指标。结果与正常对照组比较,冠心病患者肱动脉内皮依赖性血管舒张功能明显减退,血清一氧化氮浓度降低。卡维地洛可改善血管内皮依赖性舒张功能,升高血清一氧化氮浓度(P<0.01),并且血管内皮依赖性舒张功能与血清一氧化氮浓度正相关(r=0.747,P<0.01)。结论卡维地洛通过增加血清一氧化氮浓度改善冠心病患者的血管内皮功能,该作用可能是其防治冠心病的机制之一。
Objective To investigate the changes of endothelium-dependent vasodilatation and serum nitric oxide in patients with coronary heart disease (CHD) and to observe the effect of carvedilol on it. Methods The endothelium - dependent vasodilation of brachial artery in each group was detected by high resolution ultrasound technique and the level of serum nitric oxide was determined by nitrate reductase method. After 8 weeks of drug intervention retest these indicators. Results Compared with the normal control group, the endothelium-dependent vasodilation of brachial artery in patients with coronary heart disease was significantly decreased and the serum nitric oxide concentration was decreased. Carvedilol improved endothelium-dependent vasodilatation and increased serum nitric oxide (P <0.01), and endothelium-dependent vasodilation was positively correlated with serum nitric oxide (r = 0.747, P <0.01) . Conclusion Carvedilol can improve vascular endothelial function in patients with coronary heart disease by increasing serum nitric oxide concentration, which may be one of the mechanisms of its prevention and treatment of coronary heart disease.