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目的探讨胶质瘤术后早期癫痫发作的危险因素。方法对2010年1月～2011年12月我院接受开颅手术的256例胶质瘤临床资料进行单因素及多因素Logistic回归分析。结果术后早期癫痫发作的患者16例,发生率为6.25%,其中部分性发作7例(43.75%),全身强直阵挛性发作9例(56.25%),癫痫持续状态1例(6.25%)。单因素分析显示,术前癫痫史、肿瘤位置、术后是否水肿明显及瘤腔是否有出血与胶质瘤术后早期癫痫发作相关(P<0.05),进一步多因素Logistic回归分析,结果显示仅术前癫痫史、肿瘤位置及瘤腔是否出血为危险因素,其OR值分别为4.339、3.073、2.771。结论术前癫痫史、肿瘤位置及瘤腔是否出血是幕上胶质瘤术后早期癫痫的发生的危险因素。
Objective To investigate the risk factors of early postoperative epileptic seizures in gliomas. Methods The clinical data of 256 patients with glioma who underwent craniotomy from January 2010 to December 2011 in our hospital were analyzed by single factor and multivariate Logistic regression analysis. Results Sixteen patients had early epileptic seizures, with a rate of 6.25%. Among them, partial seizures occurred in 7 patients (43.75%), general tonic clonic seizures in 9 patients (56.25%) and status epilepticus in 1 patient (6.25% . Univariate analysis showed that the history of preoperative epilepsy, location of the tumor, postoperative edema and whether there is bleeding in the tumor cavity and early postoperative glioma epilepsy (P <0.05), further multivariate logistic regression analysis showed that only Preoperative epilepsy history, location of the tumor and whether the hemorrhage of tumor cavity were risk factors, the OR values were 4.339, 3.073, 2.771 respectively. Conclusion Preoperative epilepsy history, tumor location and aneurysm are the risk factors of epilepsy in early stage of supratentorial glioma postoperatively.