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为研究血清β２－微球蛋白（β２－Ｍ）及血清Ⅲ型前胶原（ＰＣⅢ）含量与肝炎病理变化的关系，对１１０各型病毒性肝炎患者在行肝活检同时，用ＲＩＡ法测定血清β２－Ｍ及ＰＣⅢ含量。肝炎病理变化用ＨＡＩ标准记分判定。结果发现血清β２－Ｍ含量与肝细胞坏死程度及门管区炎症程度密切相关（γ＝０６７０；Ｐ＜００１）；血清ＰＣⅢ含量与肝纤维化程度密切相关（γ＝０６６８，Ｐ＜００１）。提示血清β２－Ｍ含量测定有助于对肝实质炎症活动程度的判断；血清ＰＣⅢ含量变化对判断肝纤维化及肝硬化程度有一定价值
In order to study the relationship between serum β2-microglobulin (β2-M) and serum type Ⅲ procollagen (PCⅢ) and the pathological changes of hepatitis, 110 liver biopsy samples were collected simultaneously with liver biopsy. Serum β2 -M and PCⅢ content. Pathological changes of hepatitis using HAI standard score. The results showed that serum β2-M level was closely related to the degree of hepatocellular necrosis and inflammation in portal area (γ = 0.670; P <0.01). The serum PCⅢ level was closely related to the degree of hepatic fibrosis (γ = 0.668, P <001). It is suggested that the determination of serum β2-M content is helpful to judge the degree of hepatic parenchymal inflammatory activity. The change of serum PCⅢ level is of certain value in judging the degree of liver fibrosis and cirrhosis