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本文研究了碘化二甲基木防己碱(DTI)对N_2受体的拮抗作用,并以箭毒为对照。在DTI的作用下,ACh对蟾蜍腹直肌的累加剂量—效应％曲线平行右移,测得其pA_2为5.73,K_B为2.90X 10~(-6)M;而箭毒分别为5.89和2.84X 10~(-6)M。以log(~(X-1)对DTI浓度的负对数(-log~[B])作图,其回归线斜率为-0.92;箭毒的回归线斜率为-0.95,均同竞争性拮抗剂的理论斜率-1相接近。结果表明,DTI对N_2受体的拮抗性质为竞争性拮抗、其对N_2受体的亲和力与箭毒相当。
In this paper, the antagonism of dimethylstilbin iodide (DTI) on N 2 receptor was studied and the arrowhead strain was used as control. Under the action of DTI, the cumulative dose-effect% curve of ACh to the rectus abdominis of right side of Bufo bufo gargarizans moved parallel to the right, and its pA_2 was 5.73 and K_B was 2.90X 10 ~ (-6) M; X 10 ~ (-6) M. The slope of the regression line was -0.92 with the log (-log ~ [B]) of log (~ (X-1) versus the negative logarithm of DTI concentration; the slope of the regression line of arrowhead poison was -0.95, both of which were the same as the competitive antagonist The theoretical slope of -1 is close.The results show that the antagonistic nature of DTI to N 2 receptor is competitive antagonism and its affinity to N 2 receptor is comparable to that of arrow poison.