1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸-N-羟基琥珀酰亚胺酯是一种新型双功能螯合剂,传统合成方法副产物多、重复性差、纯度和产率较低。本研究对反应关键步骤的催化剂、溶剂、后处理进行改进,从而得到了合成目标产物的最佳方法。实验结果表明,改进后的工艺路线条件温和、重复性好、成本较低。产物纯度达98%以上,总收率达39.3%。 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-N-hydroxysuccinimide ester is a novel bifunctional chelating agent with many byproducts , Poor reproducibility, low purity and yield. In this study, the key steps of the reaction catalyst, solvent, post-treatment is improved, resulting in the synthesis of the target product the best way. The experimental results show that the improved process route has mild conditions, good repeatability and low cost. Product purity of more than 98%, the total yield of 39.3%.