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对50例空腹血糖≥10.0mmol/L的初诊2型糖尿病患者,应用胰岛素泵输注赖脯胰岛素进行为期2周的强化治疗,采用口服葡萄糖耐量试验及胰岛素释放试验测定治疗前后血糖、胰岛素水平并比较血清超敏C-反应蛋白(hs-CRP)的变化,并计算胰岛β细胞分泌指数(Homa-IS)、胰岛素抵抗指数(HOMA-IR),并随访6个月,观察血糖变化情况。结果患者FPG、2hPG、Homa-IR、hs-CRP值均较治疗前显著下降(P<0.05),FIns2、h FIns、Homa-IS值均较治疗前显著升高(P<0.05)。随防6个月,其中15例仅通过饮食控制及运动可获得血糖的理想控制。结论初诊2型糖尿病患者经短期胰岛素泵强化治疗后可快速控制血糖,显著改善胰岛β细胞功能,减轻胰岛素抵抗。胰岛素泵强化治疗宜在T2DM患者的初诊早期应用。
Fifty patients with newly diagnosed type 2 diabetes with fasting blood glucose> 10.0 mmol / L were treated with insulin pump infusion of insulin lispro for 2 weeks. The oral glucose tolerance test and insulin release test were used to determine the blood glucose and insulin levels before and after treatment The changes of serum hs-CRP were compared. Homa-IS and HOMA-IR were calculated and followed up for 6 months to observe the change of blood glucose. Results The levels of FPG, 2hPG, Homa-IR and hs-CRP were significantly decreased (P <0.05), and the values of FIns2, h FIns and Homa-IS were significantly higher than those before treatment (P <0.05). With anti-6 months, of which 15 cases only through diet control and exercise can be the ideal control of blood glucose. Conclusions The newly diagnosed type 2 diabetic patients can quickly control their blood glucose after intensive insulin pump therapy, significantly improve the function of islet β cells and reduce insulin resistance. Insulin pump intensive treatment should be early diagnosis of T2DM patients.