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目的采用Meta分析方法,计算2011年1月至2014年4月中国公开发表文献的艾滋病母婴传播率,评价母婴阻断效果。方法检索万方数据资源系统、中国医院知识库和Pubmed数据库,收集关于艾滋病母婴阻断效果的文献,参照疾病患病率或发病率研究质量评价准则,评价文献的质量,对纳入的文献进行异质性检验,采用随机效应或固定效应模型合并效应量,评价发表偏倚,运用敏感度分析评价文献质量和文献样本量对研究结果的影响。结果共纳入19篇文献,总样本量4787人,总阳性数113人,合并结果后母婴传播发生率为2.27%[95%可信区间(CI):1.43%~3.59%]。亚组分析结果表明,不同经济发展水平、不同疫情程度地区间艾滋病母婴传播率差异无统计学意义。通过敏感度分析删除1篇多地研究后,Meta分析结果略有降低。结论通过实施规范性母婴阻断措施后,中国艾滋病母婴阻断效果与发达国家类似,但母婴阻断工作仍存在问题,亟须加强。
Objective To analyze the maternal-infant transmission rate of HIV / AIDS in China published from January 2011 to April 2014 by Meta-analysis, and to evaluate the effect of maternal and child blockage. Methods We searched Wanfang Data Resource System, Chinese Hospital Knowledge Base and Pubmed Database to collect the literature about the blocking effect of HIV / AIDS in maternal and infants. The quality of the literature was evaluated according to the criteria of the disease prevalence or morbidity research quality, Heterogeneity test, using random effects or fixed effects model combined effect amount, publication bias evaluation, the use of sensitivity analysis to evaluate the literature quality and literature sample size on the results of the study. Results A total of 19 articles were included, with a total sample size of 4787 and a total of 113 positives. The incidence of mother-to-child transmission was 2.27% [95% confidence interval (CI): 1.43% -3.59%] after the combination. Sub-group analysis showed that there was no significant difference in the rates of mother-to-child transmission of HIV among different levels of economic development and between different levels of outbreaks. Meta analysis decreased slightly after deleting more than one study by sensitivity analysis. Conclusions After the implementation of normative maternal and infant blockade measures, the blocking effect of mother-to-child HIV / AIDS in China is similar to that in developed countries. However, there are still problems in maternal and child blockade, which urgently needs to be strengthened.