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目的探讨组织结构声学定量技术(acoustic structure quantification,ASQ)在急性肝损伤中的应用价值。方法利用ASQ技术对43例急性肝损伤患者急性期、恢复期及40例同期健康体检者进行肝脏ASQ分析,并将急性期、恢复期的ASQ参数与实验室检查结果相对比。结果急性期与恢复期ASQ参数总的众数值(Total Mode)、总的平均值(Total Average)、红色曲线下众数值(Red Mode)、红色曲线下平均值(Red Average)、蓝色曲线下众数值(BlueMode)、蓝红曲线下面积比(FD-Ratio)差异有统计学意义(P均<0.05),蓝色曲线下均值(Blue Average)、蓝色曲线下离散度(Blue SD)、红色曲线下离散度(Red SD)差异无统计学意义(P均>0.05)。急性期与正常对照组ASQ参数To-tal Mode、Total Average、Red Mode、Red Average、Red SD、Blue Mode、Blue Average、FD-Ratio差异有统计学意义(P均<0.05),恢复期与正常对照组ASQ参数Total Mode、Total Average、Red Mode、Red Average差异有统计学意义(P均<0.05)。急性期参数Total Mode值与总胆红素、直接胆红素呈负性相关,且相关系数绝对值最大(r均=-0.429,P<0.05);恢复期参数FD-Ratio与胆碱酯酶呈负性相关,且相关系数绝对值最大(r均=-0.378,P<0.05)。结论 ASQ技术可作为实验室检查以外,评价急性肝损伤后恢复情况的一种较客观的诊断方法。
Objective To investigate the value of tissue structure acoustic quantification (ASQ) in acute liver injury. Methods ASQ was used to analyze the ASQ of 43 patients with acute liver injury during acute phase, convalescence phase and 40 healthy subjects at the same period. The ASQ parameters of acute and convalescent phase were compared with those of laboratory test. Results Acute and convalescent ASQ parameters Total Mode, Total Average, Red Mode, Red Average, BlueMode and FD-Ratio had significant difference (P <0.05), Blue Average, Blue SD, There was no significant difference in Red SD between red curve (P> 0.05). There were significant differences in ASQ parameters of To-tal Mode, Total Average, Red Mode, Red Average, Red SD, Blue Mode, Blue Average and FD-Ratio between acute phase and normal control group (all P <0.05) The differences of ASQ parameter Total Mode, Total Average, Red Mode and Red Average in the control group were statistically significant (all P <0.05). Total Mode of acute phase parameters and total bilirubin, direct bilirubin was negative correlation, and the absolute maximum correlation coefficient (r = -0.429, P <0.05); recovery parameters FD-Ratio and cholinesterase Was negative correlation, and the absolute maximum correlation coefficient (r = -0.378, P <0.05). Conclusion ASQ can be used as a more objective diagnostic method for evaluating the recovery of acute liver injury besides laboratory tests.