论文部分内容阅读
目的探讨艾滋病患者浅表淋巴结肿大与机体免疫力的相关性。方法选取2015年7月—2016年12月于赣州市第五人民医院收治的人类免疫缺陷病毒(HIV)感染患者598例,检测患者外周血CD_4~+T淋巴细胞计数,并对其中合并有浅表淋巴结肿大者进行淋巴结切除活组织病理学检查。结果在598例HIV感染者中,合并浅表淋巴结肿大63例,发生率为10.5%,其中浅表淋巴结肿大以颈部多见者41例(65.1%),颌下淋巴结肿大者9例(14.3%),锁骨上淋巴结肿大者6例(9.5%),腋窝淋巴结肿大者4例(6.3%),腹股沟淋巴及肿大者6例(9.5%),其中存在3例患者颈部和腹股沟同时肿大淋巴结。经Spearman相关性分析结果显示,浅表淋巴结肿大与CD_4~+T淋巴细胞计数呈负相关(R=-1,P<0.001),浅表淋巴结肿大病因与CD_4~+T淋巴细胞计数无相关性(R=-0.580,P=0.172)。结论 CD_4~+T淋巴细胞计数越低,浅表淋巴结肿大率越高,而在浅表淋巴结肿大的病理学类型中,结核病患者所占比例最高。因此检测外周血CD_4~+T淋巴细胞计数对艾滋病患者浅表淋巴结肿大的早期诊断和指导临床治疗具有重要参考作用。
Objective To investigate the correlation between superficial lymph nodes and immune in AIDS patients. Methods 598 cases of human immunodeficiency virus (HIV) infection in the Fifth People ’s Hospital of Ganzhou City from July 2015 to December 2016 were selected. The count of CD 4 + T lymphocytes in peripheral blood of patients was detected, Lymphadenectomy for lymph node biopsy biopsy. Results Among the 598 HIV-infected patients, 63 cases were complicated with superficial lymph nodes, the incidence rate was 10.5%. Among them, 41 cases (65.1%) had superficial cervical lymph nodes and 9 cases (65.1%) had enlarged cervical lymph nodes. (14.3%), 6 cases (9.5%) of supraclavicular lymph nodes, 4 cases (6.3%) of axillary lymph nodes and 6 cases (9.5%) of inguinal lymphadenopathy. There were 3 cases of neck Department and groin enlargement of lymph nodes. Spearman correlation analysis showed that there was a negative correlation between superficial lymph node enlargement and CD_4 ~ + T lymphocyte count (R = -1, P <0.001), superficial lymph node enlargement and CD_4 ~ + T lymphocyte count Correlation (R = -0.580, P = 0.172). Conclusion The lower the count of CD_4 ~ + T lymphocytes, the higher the rate of superficial lymph nodes, and the highest rate of pathological types of superficial lymph nodes. Therefore, the detection of peripheral blood CD_4 ~ + T lymphocyte count of AIDS patients with superficial lymph nodes early diagnosis and guidance of clinical treatment has an important reference.