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AIM:To study the alteration of nuclear matrix proteins(NMPs)in gastric cancer.METHODS:The NMPs extracted from 22 cases of gastriccancer and normal gastric tissues were investigated bySDS-PAGE technique and the data were analyzed usingGenetools analysis software.RESULTS:Compared with normal gastric tissue,theexpression of 30 ku and 28 ku NMPs in gastric cancerdecreased significantly(P=0.002,P=0.001,P<0.05).Nosignificant difference was found in the expression of thetwo NMPs between the various differentiated grades(P=-0.947,P=-0.356)and clinical stages of gastric cancer(P=0.920,P=0.243,P>0.05).CONCLUSION:The results suggested that the alterationof NMPs in gastric cancer occurred at the early stage ofgastric cancer development.
AIM: To study the alteration of nuclear matrix proteins (NMPs) in gastric cancer. METHODS: The NMPs extracted from 22 cases of gastriccancer and normal gastric tissues were investigated by SDS-PAGE technique and the data were analyzed using Genetools analysis software .RESULTS: Compared with Normal gastric tissue, the expression of 30 ku and 28 ku NMPs in gastric cancer significantly increased (P = 0.002, P = 0.001, P <0.05) .Nosignificant difference was found in the expression of thetwo NMPs between the various differentiated grades (P = -0.947 , P = -0.356) and clinical stages of gastric cancer (P = 0.920, P = 0.243, P> 0.05) .CONCLUSION: The results suggested that the alteration of NMPs in gastric cancer occurred at the early stage of gastric cancer development.