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目的:探讨短期胰岛素强化治疗对2型糖尿病(T2DM)患者糖化血红蛋白(HbAlc)的影响。方法:选取阳西县中医院2013年1月至2016年1月收治的糖尿病患者120例,根据治疗方案的不同分为观察组(n=60)和对照组(n=60),两组均治疗1个月,随访6个月,于治疗前后分别监测两组患者FPG及餐后2 h血糖、HbAlc水平,并比较两组患者HbAlc及血糖,并采用logistic回归分析HbAlc的影响因素。结果:治疗后与治疗前相比,两组患者血糖、HbAlc水平控制均较好,但观察组FPG及餐后2 h血糖、HbAlc水平均优于对照组;观察组患者治疗后HbAlc达标率与对照组HbAlc达标率相比明显升高;观察组血糖达标时间明显短于对照组,差异有统计学意义(P<0.05);logistic回归分析结果显示,年龄、病程、并发症均为HbAlc不达标的独立因素(P<0.05)。结论:短期胰岛素强化治疗T2DM能有效提高HbAlc达标率,改善血糖情况,且HBA1c达标率与T2DM患者的年龄、病程及并发症情况有关,可根据患者个体情况进一步优化治疗方案。
Objective: To investigate the effect of short-term intensive insulin therapy on glycosylated hemoglobin (HbAlc) in type 2 diabetes mellitus (T2DM). Methods: A total of 120 diabetic patients admitted from January 2013 to January 2016 in Yangxi Hospital of Traditional Chinese Medicine were divided into observation group (n = 60) and control group (n = 60) according to the different treatment regimens. The patients were followed up for 6 months. Before and after treatment, the levels of FPG and 2 h postprandial blood glucose and HbAlc in both groups were monitored. HbAlc and blood glucose were compared between the two groups. Logistic regression analysis was used to analyze the influencing factors of HbAlc. Results: After treatment, the levels of HbA1c and blood glucose in the two groups were all better than those before treatment, but the levels of FPG, 2h postprandial blood glucose and HbAlc in the observation group were better than those in the control group. The compliance rates of HbAlc and (P <0.05). The results of logistic regression analysis showed that the age, course of disease and complications were all non-compliance of HbA1c Independent factors (P <0.05). Conclusion: Short-term intensive insulin treatment of T2DM can effectively improve the compliance rate of HbAlc and improve the blood glucose level. The compliance rate of HBA1c is related to the age, course of disease and complications of T2DM patients. The treatment regimen can be further optimized according to individual patients.