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目的分析宁波市不同时期肺结核患者耐药状况,为结核病控制规划的顺利实施提供科学依据。方法回顾分析宁波市1999年10月~2000年3月开展的耐药监测资料(设为Ⅰ组)及2009年7月~2009年12月开展的耐药监测资料(设为Ⅱ组)。对组间耐药情况和不同抗结核药物的耐药顺位进行比较分析。统计学处理采用SPSS 13.0统计软件,率的比较用χ2检验,P<0.05为差异有统计学意义。结果Ⅰ组肺结核病例总耐药率为22.4%(57/254),Ⅱ组肺结核病例总耐药率为32.1%(124/386),总体耐药率有上升趋势,经统计学处理,差异有统计学意义(χ2=7.082,P<0.05);Ⅰ组肺结核病例耐多药率为6.3%(16/254),Ⅱ组肺结核病例耐多药率为8.0%(31/386),两组比较,差异无统计学意义。结论宁波市肺结核病耐药形式依然严峻,今后须进一步加强耐药结核病的防治工作。
Objective To analyze the drug resistance of patients with pulmonary tuberculosis in different periods in Ningbo and to provide a scientific basis for the successful implementation of tuberculosis control programs. Methods A retrospective analysis was conducted on the drug resistance surveillance data (set as Ⅰ) and the drug resistance monitoring data from July 2009 to December 2009 (set Ⅱ) from October 1999 to March 2000 in Ningbo City. To compare the drug resistance of different groups and the anti-tuberculosis drug resistance cis-positions. Statistical analysis using SPSS 13.0 statistical software, rate comparison using χ2 test, P <0.05 for the difference was statistically significant. Results The total drug resistance rate of tuberculosis cases in group Ⅰ was 22.4% (57/254). The total drug resistance rate of tuberculosis cases in group Ⅱ was 32.1% (124/386). The overall drug resistance rate had an upward trend. According to the statistical analysis, (Χ2 = 7.082, P <0.05). The rate of multidrug-resistant pulmonary tuberculosis in group I was 6.3% (16/254), that of group II was 8.0% (31/386), the difference was statistically significant ,The difference was not statistically significant. Conclusion The form of drug-resistant tuberculosis in Ningbo City is still severe, so it is necessary to further strengthen the prevention and treatment of drug-resistant tuberculosis in the future.