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应用简易致敏红细胞血小板血清学技术（SEPSA）对1201例正常孕妇和52例早期流产患者的母婴免疫血小板同种抗体进行了研究,显示早期流产妇女的血小板抗体阳性率为21.15％。显著高于正常孕妇（3.66％）及经产妇（1.37％）血小板抗体与早期流产的发病有显著相关性（X~2=29.32,P<0.005）。血小板抗体免疫球蛋白类型为IgG型,仅1例又有IgM型,以血小板特异性抗体与HLA抗体并存者占人多数（54.54％）。在查出的55例血小板抗体阳性孕妇中有6例发生新生儿同种免疫性血小板减少性紫癜症（NAITP）,并证实HPA-5b（Br~α）抗体是引起我国NAITP的主要抗体。我们对其中3例抗体效价高于1:32的孕妇进行血浆党换治疗,有效地防止了血小板减少性紫癜及早期流产的发生。
The maternal and infant immune platelet alloantibodies of 1201 normal pregnant women and 52 cases of early abortion were studied by using simple sensitized erythrocyte platelet serology (SEPSA). The positive rate of platelet antibodies in early abortion women was 21.15%. Significantly higher than the normal pregnant women (3.66%) and the mothers (1.37%) platelet antibodies and the incidence of early miscarriage has a significant correlation (X ~ 2 = 29.32, P <0.005). Platelet antibody immunoglobulin type IgG type, only 1 and IgM type, with platelet-specific antibodies and HLA antibodies accounted for the majority (54.54%). In the 55 cases of platelet-positive pregnant women detected in 6 cases of neonatal alloimmune thrombocytopenic purpura (NAITP), and confirmed that HPA-5b (Br ~) antibody is the main antibody NAITP in our country. We in three cases of antibody titer higher than 1:32 in pregnant women with plasma exchange treatment, effectively prevent the occurrence of thrombocytopenic purpura and early abortion.