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在世界范围内,结直肠癌(colorectal cancer,CRC)的发病率处于恶性肿瘤的第三位,仅次于胃癌和食管癌;西方发达国家CRC仅次于肺癌,居第二位;我国近20年来CRC的发病率在逐渐增加,发达地区如广东和香港发病率已接近西方发达国家[1]。其中DNA甲基化与肿瘤的相关性成为了一个研究热点。研究表明,在CRC发生、发展过程中存在许多特异性的DNA异常甲基化。2011年美国[2]
In the world, the incidence of colorectal cancer (CRC) is third in malignant tumors, second only to gastric cancer and esophageal cancer; Western developed countries are second only to lung cancer after CRC, ranking second in China; nearly 20% The incidence of CRC has gradually increased in recent years. The incidence rates in developed areas such as Guangdong and Hong Kong are close to those in western developed countries [1]. DNA methylation and tumor correlation has become a hot research topic. Studies have shown that in the occurrence and development of CRC, there are many specific DNA abnormal methylation. 2011 United States [2]