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为探明云南锡矿矿工肺癌高发的病因，进行了一系列实验性肺癌研究，总结如下：作为模型，甲基胆蒽，苯并芘及二乙基亚硝胺均能诱发金仓鼠肺癌。实验性肺癌病因研究中，云锡矿粉及其所含砷、铅、铁、铝、钛、锌、铬、锰、锆、镍、镉、铍、钴、银、银等１５种无机化学成分（代号ＣＭ＿１）和砷、铅、铁、铬、镍、镉、被等７种无机化学成分（代号ＣＭ＿２）均可诱发金仓鼠肺癌。ＣＭ＿１及ＣＭ＿２的Ａｍｅｓ试验、细胞转化试验均为阳性。炼厂烟尘Ａｍｅｓ试验及诱癌实验亦均为阳性，表明云锡矿粉及其部分成分的混合尘和炼厂烟尘均有致肺癌效应。因此云锡矿工肺癌病因应为多因素综合作用所致。
In order to explore the cause of the high incidence of lung cancer among miners of Yunnan tin mines, a series of experimental lung cancer studies were conducted and summarized as follows: As a model, methylcholanthrene, benzopyrene and diethylnitrosamine can induce hamster lung cancer. In the study of the etiology of experimental lung cancer, Yun tin powder and 15 inorganic chemical components such as arsenic, lead, iron, aluminum, titanium, zinc, chromium, manganese, zirconium, nickel, cadmium, barium, cobalt, silver, and silver are contained. (Colony No. CM_1) and seven kinds of inorganic chemical components (code CM_2) such as arsenic, lead, iron, chromium, nickel, cadmium, etc. can all induce hamster lung cancer. Ames test and cell transformation test of CM_1 and CM_2 were positive. The Ames test and carcinogenicity tests in the refinery were all positive, indicating that the mixed dust of the tin-tin ore and some of its components and the smoke from the refinery all caused the lung cancer effect. Therefore, the cause of lung cancer in Tin Tin miners should be due to a combination of multiple factors.