肾脏替代治疗是严重的急性肾损伤治疗的基石,虽然在过去的几十年中,肾脏替代治疗技术得到了明显的改进,但是关于治疗的时机、治疗模式的选择以及治疗的剂量仍然存在争论,关于急性肾损伤的肾脏替代治疗的最佳方式仍不确定,本文从以上3个方面进行论述,回顾一些临床证据并对将来的更进一步的研究提出建议。 Renal replacement therapy is the cornerstone of the treatment of severe acute kidney injury. Although there has been a significant improvement in renal replacement therapy over the past few decades, there is still debate about the timing of treatment, the choice of treatment modalities, and the dose to be treated. The best way of renal replacement therapy for acute kidney injury remains uncertain. This article discusses the above three aspects, reviews some of the clinical evidence and makes recommendations for further research in the future.