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1966至1979年,美国东南地区滋养叶肿瘤中心治疗转移性滋养叶肿瘤病人126人,其中63例应属预后差的.预后差的标准是:(1)治疗前尿绒毛膜促性腺激素(以下简称hCG)高于100,000U/24小时尿,或血清β-hCG放免测定高于40,000mU/ml.(2)有脑或肝转移.(3)单一药物化疗失败.(4)足月妊娠后的滋养叶肿瘤.(5)起病超过4个月.自1976年以来,该中心对预后差的18名病人采用改良的Bagshawe(以下简称B氏)化疗方案,18例中10例获得持续缓解.
Between 1966 and 1979, there were 126 patients with metastatic trophoblastic tumor in the Trophic Tumor Center of the South East United States, 63 of whom had poor prognosis. The criteria for poor prognosis were: (1) Pre-treatment urinary human chorionic gonadotropin Referred to as hCG) higher than 100,000U / 24 hours urine, or serum β-hCG radioimmunoassay was higher than 40,000mU / ml. (2) brain or liver metastasis. (3) single drug chemotherapy failed. (5) onset more than 4 months since 1976, the center of poor prognosis of 18 patients with improved Bagshawe (hereinafter referred to as B’s) chemotherapy, 18 cases of 10 cases of sustained remission .