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目的：探讨ＣＤ４４（ＣＤ４４ｓ 及ＣＤ４４ｖ６）和ｎｍ２３ 基因产物表达与食管癌临床病理指标及预后的关系。方法：应用ＳＰ免疫组化染色法对５４ 例食管癌标本进行ＣＤ４４ 、ｎｍ２３ 基因产物测定，并对其中４１ 例进行了术后３ 年随访。结果：ＣＤ４４ｖ６ 基因产物的高表达和ｎｍ２３ 基因产物的低表达与食管癌的浸润转移、复发和预后均有关（Ｐ＜００５） 。食管癌中ＣＤ４４ｖ６ 和ｎｍ２３ 表达呈负相关（Ｐ＜ ００５）。ＣＤ４４ｖ６ 阳性表达伴ｎｍ２３ 阴性表达的患者发生淋巴结转移的可能性大。结论：ＣＤ４４（ 尤其是ＣＤ４４ｖ６）和ｎｍ２３ 在食管癌中的表达与食管癌的发生发展、侵袭转移和预后密切相关，ＣＤ４４ｖ６ 和ｎｍ２３ 表达在食管癌淋巴结转移中起协同作用，可做为临床预测侵袭转移和估计预后的一个重要参考指标
Objective: To investigate the relationship between the expression of CD44 (CD44s and CD44v6) and nm23 gene products and clinicopathological parameters and prognosis of esophageal cancer. Methods: SP immunohistochemical staining was used to detect the CD44 and nm23 gene products in 54 specimens of esophageal cancer, and 41 of them were followed up for 3 years. Results: High expression of CD44v6 gene product and low expression of nm23 gene product were associated with invasion, metastasis, recurrence, and prognosis of esophageal cancer (P<005). There was a negative correlation between the expression of CD44v6 and nm23 in esophageal cancer (P<0.05). Patients with positive CD44v6 expression with nm23-negative expression are more likely to have lymph node metastases. Conclusion: The expression of CD44 (especially CD44v6) and nm23 in esophageal cancer is closely related to the occurrence, development, invasion, metastasis and prognosis of esophageal cancer. The expression of CD44v6 and nm23 may play a synergistic role in lymph node metastasis of esophageal cancer and can be used as a clinical predictor of invasion. An important reference for metastasis and estimation of prognosis