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目的：探讨女性首发精神分裂患者骨密度的变化状况。方法对90例女性首发精神分裂患者的临床资料进行回顾性分析,并统计不同年龄段患者骨密度的变化状况。结果本组患者骨密度异常发生率为85.6%,其中骨质疏松发生率为55.6%、骨量减少为30.0%。≥50岁组骨质疏松发生率最高(88.9%),显著高于<40岁组(40.0%)(χ2=7.18,P <0.01),且重度骨质疏松症发生率(55.6%)显著高于<40岁组(2.2%)及≥40岁组(5.6%)(P <0.05)。患者骨密度与体质量呈显著正相关(P <0.05)。结论女性首发精神病分裂症患者是发生骨质疏松症的高危患病群体,且体质量是影响其骨密度的相关危险因素。“,”Objective To explore the skeletal density changes in female first-episode schizophrenics.Meth-ods Retrospective analyses of clinical data were carried out in 90 female first-episode schizophrenics and skeletal density changes of patients with different age groups counted.Results The incidence of bone density abnormality in the patients was 85.6%,osteoporosis 55.6% and osteopenia 30.0%.The incidence of osteoporosis was the highest in age group ≥50 (88.9%)and significantly higher than that in age group< 40 (40.0%,χ2 =7.18,P <0.01),and so was that of severe osteoporosis (55.6%)than in age group <40 (2.2%)and ≥ 40 (5.6%)(P <0.05).Patient’s bone density was positively related to body mass sig-nificantly (P <0.05).Conclusion Female first-episode schizophrenics are high-risk group suffering from osteoporosis and body mass is the correlated risk factor influencing bone mineral density.