Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidat

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CallicarpabodinieriisaChinesetraditionalmedicineherbwithanti-inflammatory activityinclinic.Herein, we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids J and K (1 and 2) and one known compound (3) isolated from the leaves and twigs of this plant. Their chemical structures were elucidated by detailed spectrometry data analysis and DP4+NMR calculation methods. Hypothetical biosynthetic pathways of 1-3 were preliminarily speculated. Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro.
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