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目前,结直肠癌的多学科综合治疗理念被越来越多的人接受。同时,分子分型指导下的个体化治疗也日趋成熟。结直肠癌是高度异质性肿瘤,其发病由一系列遗传事件和表观遗传学事件所造成。随着大数据以及精准医疗时代的到来,结直肠癌分子分型,包括左、右半结肠以及分子生物标志物的分型越来越重要。如何识别结直肠癌的异质性和个体间差异、如何更好地进行精准治疗,将成为未来结直肠癌治疗的焦点。
At present, the multi-disciplinary treatment concept of colorectal cancer is accepted by more and more people. At the same time, the individualized treatment under the guidance of molecular typing has become increasingly mature. Colorectal cancer is a highly heterogeneous tumor whose onset is caused by a series of genetic and epigenetic events. With the advent of big data and the era of precision medicine, molecular typing of colorectal cancer, including the left and right colon, and the classification of molecular biomarkers is becoming more and more important. How to identify the heterogeneity of colorectal cancer and individual differences, how to better accurate treatment, will become the focus of future colorectal cancer treatment.