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作者报告不同类型心衰患者(20例,男9例,女11例,按NYHA心功能均为Ⅳ级)血浆中肾素活性(PRA)、血管紧张素Ⅱ(ATⅡ)、血清钠和24h尿钠排出量;健康44人作对照,探讨钠对心衰患者PRA和AT_Ⅱ浓度的影响。结果表明。(1)左心衰患者PRA(4740±738.9ng/L·h~(-1))和AT_Ⅱ(80.69±9.20ng/L)浓度高于健康人(分别为630±98.0ng/L·h~(-1)和21.36±1.59ng/L),也高于右心衰患者(分别为270±102.9ng/L·h~(-1)和25.00±7.10ng/L)。(2)左心衰患者属高肾素型,右心衰患者则属低肾素型或正常肾素型。(3)心衰患者PRA和AT_Ⅱ浓度与尿钠排出量呈负相关。
The authors report the changes in plasma renin activity (PRA), angiotensin Ⅱ (ATⅡ), serum sodium and 24 h urine in patients with different types of heart failure (20 males, 9 males and 11 females with NYHA cardiac function grade IV) Sodium excretion; healthy 44 people as a control, to explore the impact of sodium on PRA and AT Ⅱ concentration in patients with heart failure. The results show. (1) The concentrations of PRA (4740 ± 738.9ng / L · h -1) and AT_Ⅱ (80.69 ± 9.20ng / L) in patients with left heart failure were significantly higher than those in healthy people (630 ± 98.0ng / L · h ~ (-1) and 21.36 ± 1.59ng / L respectively), and were also higher than those in patients with right heart failure (270 ± 102.9ng / L · h -1 and 25.00 ± 7.10ng / L, respectively). (2) patients with left heart failure are high renin type, right heart failure patients are low renin type or normal renin type. (3) The concentrations of PRA and AT_II in patients with heart failure were negatively correlated with the urinary sodium excretion.