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PURPOSE:To establish scientific relationship between relative humidity(RH)and aqueous tear evaporation to elucidate possible significance of this relationship in normals and aqueous tear deficiency patients.DESIGN:Prospective xperimental laboratory study.METHODS:Ocular surface evaporation was determined using evaporometry and calculated for two ranges of RH,25% to 35%,and 35% to 45% in a randomized clinical patient population.RESULTS:Average evaporative rate in the higher humidity range was between 0.029± 0.009 through 0.043± 0.016 μ l/cm2/min.At lower humidity,range was between 0.044± 0.013 through 0.058± 0.018 μ l/cm2/min.Differences in the corresponding evaporative rates were statistically significant(between P<.003 through P<.043)for each analysis.CONCLUSIONS:A decrease of 10% RH resulted in an average difference of between 28.33% to 59.42% increase in evaporation.The increase in evaporation at lower humidity has significant clinical implications for patients with aqueous deficient dry eyes,and possibly those undergoing laser-assisted in situ keratomileusis(LASIK).
PURPOSE: To establish scientific relationship between relative humidity (RH) and aqueous tear evaporation to elucidate possible significance of this relationship in normals and aqueous tear deficiency patients. DESIGN:Prospective xperimental laboratory study. METHODS: Ocular surface evaporation was determined using evaporometry and calculated for Two ranges of RH, 25% to 35%, and 35% to 45% in a randomized clinical patient population .RESULTS: Average evaporative rate in the higher humidity range was between 0.029 ± 0.009 through 0.043 ± 0.016 μl / cm2 / min. At lower humidity, range was between 0.044 ± 0.013 through 0.058 ± 0.018 μ l / cm2 / min. Differences in the corresponding evaporative rates were statistically significantly (between P <.003 through P <.043) for each analysis. of 10% RH resulted in an average difference of between 28.33% to 59.42% increase in evaporation. Increase in evaporation at lower humidity has significant clinical implications for patients with aqueous def icient dry eyes, and possibly those under laser-assisted in situ keratomileusis (LASIK).