报告1例疑似皮肌炎的播散性嗜酸性细胞胶原病。患者女,53岁。全身泛发暗褐色斑,干燥、皲裂伴瘙痒14个月,无肌肉症状。实验室及辅助检查提示,嗜酸性粒细胞增高、血清IgE升高,抗核抗体(ANA)阳性,CT示肺部多发斑片条索影,肺功能限制性通气功能障碍伴弥散功能减低,肌电图示肌源性损害,皮损组织病理提示符合结缔组织病。诊断:播散性嗜酸性细胞胶原病。 One case of disseminated eosinophilic collagen disease suspected of dermatomyositis was reported. Female patient, 53 years old. General dark brown patch of hair, dry, chapped with itching 14 months, no muscle symptoms. Laboratory and laboratory examinations showed that eosinophilia was elevated, serum IgE was elevated, anti-nuclear antibody (ANA) was positive, CT showed pulmonary multiple patches, lung function limitation ventilation dysfunction with diffuse dysfunction, and muscle Electromyography showed myogenic damage, histological lesions suggest pathological connective tissue disease. Diagnosis: disseminated eosinophilic collagen disease.