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目的 探讨在宫内低水平铅暴露状态下,新生儿脐血铅含量及初乳铅铅含量与神经行为发育的关系。方法 随机选取南京市妇幼保健院医院产科2010-01/04出生的足月新生儿170例。以脐血铅和初乳铅铅含量作为新生儿铅暴露的指标,新生儿神经行为(NBNA)发育评分作为效应指标,根据初乳铅中位数48.3μg/l,新生儿被分为高低铅两组。结果 高暴露组在新生儿主动肌张力、原始反射,和神经行为发育总评分上低于低暴露组,差异有统计学意义(P<0.05),在新生儿行为能力、被动肌张力、一般估价上差异无统计学意义。结论 初乳铅脐血铅水平和与婴儿的早期发育有关,铅可通过乳汁和脐血造成新生儿的铅接触,对新生儿婴儿早期神经行为发育产生不良影响。
Objective To investigate the relationship between cord blood lead levels and the content of lead and lead in neonatal umbilical cord blood and neurobehavioral development in low intrauterine exposure of lead. Methods A total of 170 full-term newborns were born in Nanjing MCH Hospital from January 2010 to April 2010. The cord blood lead and colostrum lead content as indicators of neonatal lead exposure, neonatal neurobehavioral (NBNA) development score as an effect index, according to colostrum median of 48.3μg / l, the newborn is divided into high and low lead Two groups. Results The high exposure group was lower than the low exposure group in total neonatal active muscle tone, primary reflex, and neurobehavioral development, with significant difference (P <0.05). The neonatal performance, passive muscle tension, The difference was not statistically significant. Conclusions Lead levels in colostrum lead and cord blood are related to the early development of infants. Lead can cause newborn lead exposure through milk and umbilical cord blood, which may adversely affect the early neurobehavioral development of newborn infants.