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目的观察递增式科里奥利(科氏)加速度刺激习服训练的效果并分析相关激素水平。方法 12名青年男性志愿者,按照首次训练运动病症状评分进行配对分组,共分为2组,分别进行连续4 d递增式科氏加速度刺激训练(A组:连续式科氏加速度每日刺激量分别为5,8,8和10 min,左右头动模式;B组:间断式科氏加速度每日刺激量分别为8,8,10和15 min,前后头动模式)。此外,所有志愿者在训练前1天和训练后1天,以及训练后1,2,3,5,9和14周分别进行前后头动和左右头动模式各2 min的科氏加速度刺激进行前庭功能的评定。以前庭刺激时的运动病症状评分和精氨酸加压素(arginine vaso-pressin,AVP)、皮质醇(cortisol,Cor)、肾素活性(renin activity,PRA)、血管紧张素(angiotensin,AII)和促肾上腺皮质激素(adrenocorticotropic hormone,ACTH)的变化水平作为评价指标。结果训练后,志愿者运动病症状评分有明显降低,训练后2周显著低于检查前水平(P<0.05)。激素指标中,AVP含量在科氏刺激前后的变化百分比与运动病症状评分之间有显著的相关性(P<0.05),Cor,PRA,AII和ACTH在各时间点无明显差别。两种刺激模式的效果没有差异。结论 4 d的递增式前庭习服训练的效果至少可以维持至2周。AVP在前庭习服效应的构建和维持中可能扮演着重要的作用。
Objective To observe the effect of incremental Coriolis acceleration training and to analyze the related hormone levels. Methods Twelve young male volunteers were paired according to the first symptom score of training motion sickness, and were divided into two groups and were respectively treated with progressive Coriolis acceleration training for 4 consecutive days (group A: continuous Koch acceleration daily stimulus 5, 8, 8 and 10 min, respectively; group B: intermittent Coriolis acceleration daily stimulation of 8, 8, 10 and 15 min, respectively, before and after the first move mode). In addition, all volunteers performed Coriolis acceleration stimulation 2 minutes before and after 1 and 2 days, and 1, 2, 3, 5, 9 and 14 weeks after training respectively Evaluation of vestibular function. The symptom scores of arrhythmia and arginine vaso-pressin (AVP), cortisol (Cor), renin activity (PRA), angiotensin (AII) ) And adrenocorticotropic hormone (ACTH) levels as indicators of evaluation. Results After training, symptom scores of motion sickness in volunteers decreased significantly, and were significantly lower than those before examinations at 2 weeks after training (P <0.05). There was a significant correlation between the percentage change of AVP content before and after Coriolis irritation and symptom score of motion sickness (P <0.05). There was no significant difference of Cor, PRA, AII and ACTH between the two groups at each time point. There is no difference between the two stimulus patterns. Conclusion The effect of 4-day incremental vestibular training can be maintained for at least 2 weeks. AVP may play an important role in the construction and maintenance of vestibular attendant effects.