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本研究通过观察小鼠在缺氧、高温、低温条件下的死亡率,以及测定大鼠在绑缚条件下肾上腺内抗坏血酸含量等指标,探讨矽肺宁(一种治疗尘肺的中成药,X)、锌(Zn)、矽肺宁-锌联合应用(X-Zn)提高机体对应激源适应能力的作用,及其可能的作用机制.研究结果表明,X具有提高小鼠抗高温、低温二项作用;Zn具有提高小鼠抗缺氧、低温二项作用;而X-Zn联合应用具有提高小鼠抗缺氧、高温、低温三项作用,并且X-Zn提高小鼠抗缺氧的作用强于Zn.给X、Zn、X-Zn的大鼠经绑缚应激后,肾上腺内抗坏血酸含量比对照组低,提示在绑缚应激时,X、Zn、X-Zn能增强下丘脑-垂体-肾上腺皮质轴兴奋性.
In this study, we investigated the mortality of mice under hypoxic, hyperthermic, and hypothermic conditions, and measured the index of adrenal ascorbic acid in the rat under binding conditions to investigate Xiaofeining (a proprietary Chinese medicine for treating pneumoconiosis, X). The combination of zinc (Zn) and silybinin-zinc (X-Zn) enhances the body’s ability to adapt to stressors and its possible mechanism. The results show that X can improve the anti-hyperthermia and hypothermia effects of mice. Zn can improve the anti-hypoxic and hypothermic effects of mice; while the combination of X-Zn can improve the anti-hypoxia, high temperature, and low temperature effects of mice, and X-Zn can enhance the anti-anoxia effect of mice stronger than Zn. X-, Zn-, and X-Zn-induced stress in the adrenal glands were lower in the adrenal glands than in the control group, suggesting that X, Zn, and X-Zn enhance the hypothalamus-pituitary at binding stress. Adrenal cortical axis excitability.