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自1991年5月~1994年5月用肾上腺皮质类固醇(ACS)治疗确诊的重症肌无力(MG)患者117例,其中110例为单纯采用ACS治疗。用量化的绝对记分法较客观地记录肌无力严重程度、疗程中的病情波动、加重程度;用相对记分法,通过治疗前后自我对比判定疗效。结果单用ACS治疗的总有效率、显效率和痊愈率依次为97.27%、79.09%和63.64%。在ACS疗程中,11.11%(13/117)患者出现肌无力症状加重,始于治疗后6.6±5.0d,持续7.2±3.0d,重度、中度和轻度加重者依次为46.15%、15.38%和38.5%。加重者中61%累及呼吸肌,甚至需用呼吸机。
A total of 117 patients with myasthenia gravis (MG) diagnosed with adrenal corticosteroids (ACS) were recruited from May 1991 to May 1994, 110 of whom were treated with ACS alone. Quantitative absolute scoring method to more objectively record the severity of myasthenia gravis, the course of the disease fluctuations and aggravate the degree; with relative scoring method, through the treatment of self-contrast to determine the efficacy. Results The total effective rate, effective rate and cure rate of single ACS treatment were 97.27%, 79.09% and 63.64%, respectively. During the ACS regimen, 11.11% (13/117) of patients experienced aggravated symptoms of myasthenia gravis beginning at 6.6 ± 5.0 days after treatment for 7.2 ± 3.0 days with severe, moderate, and mild exacerbations Followed by 46.15%, 15.38% and 38.5% respectively. 61% of the heavier involved respiratory muscles, and even need to use ventilator.