目的探讨羟苯磺酸钙对紫癜肾炎患儿24 h尿蛋白定量和尿β2微球蛋白(β2-MG)的影响。方法 86例紫癜肾炎患儿随机分为两组,观察组和对照组,各有43例。对照组采用常规治疗,观察组在常规治疗的基础上加用羟苯磺酸钙。两组共治疗8周。测定治疗前后患者的24 h尿蛋白定量,尿β2-MG。结果两组治疗后患儿的24 h尿蛋白定量均有不同程度的降低(P<0.01),并且与对照组治疗后比较,观察组降低更明显(P<0.05)。治疗后两组患儿的尿β2-MG有明显降低,并且与对照组治疗后比较,观察组降低更明显(P<0.05)。结论羟苯磺酸钙可以明显降低紫癜肾炎患儿尿β2-MG。 Objective To investigate the effects of calcium dobesilate on 24-hour urine protein and β2-microglobulin in children with purpura nephritis. Methods 86 cases of purpura nephritis children were randomly divided into two groups, observation group and control group, each with 43 cases. The control group was treated with conventional therapy. The observation group was given calcium dobesilate on the basis of routine treatment. The two groups were treated for 8 weeks. Determination of 24 h before treatment, urinary protein, urinary β2-MG. Results The 24 h urinary protein in both groups after treatment decreased to some extent (P <0.01), and compared with the control group after treatment, the decrease in the observation group was more obvious (P <0.05). After treatment, urinary β2-MG in both groups was significantly decreased, and compared with the control group after treatment, the observation group decreased more significantly (P <0.05). Conclusion Calcium dobesilate can significantly reduce urinary β2-MG in children with purpura nephritis.