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目的探讨化疗药物对卵巢癌患者血糖升高的影响。方法回顾性分析2005年1月-2010年10月在河北联合大学附属医院妇科住院236例卵巢癌(化疗前合并糖尿病者除外)患者化疗前后的血糖检测结果及影响因素。结果化疗后18例患者空腹血糖升高(7.63%),其中明确诊断为糖尿病4例(1.69%)。紫杉醇类药物对血糖的影响明显高于其他药物化疗,2组比较差异有统计学意义(P<0.05)。结论卵巢癌患者接受化疗药物后可能发生血糖异常,甚至发生糖耐量减低或糖尿病,应加强监测,及时处理。
Objective To investigate the effect of chemotherapeutic drugs on blood glucose in patients with ovarian cancer. Methods A retrospective analysis of the results of blood glucose tests and their influencing factors before and after chemotherapy in 236 patients with ovarian cancer (except pre-chemotherapy with diabetes) in Department of Gynecology, Affiliated Hospital of Hebei Union University from January 2005 to October 2010 was retrospectively analyzed. Results The fasting blood glucose was increased in 18 patients (7.63%) after chemotherapy, of which 4 cases (1.69%) were correctly diagnosed as diabetes. The effect of paclitaxel on blood glucose was significantly higher than that of other drugs, the difference between the two groups was statistically significant (P <0.05). Conclusion Ovarian cancer patients receiving chemotherapy may be abnormal blood glucose, and even impaired glucose tolerance or diabetes, should be strengthened monitoring and timely treatment.