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自从Nowell(1960)在慢性粒细胞性白血病(简称慢粒)病人中发现Ph~1染色体以来,白血病细胞的染色体研究发展很快,并观察到慢粒急变以及其他急性白血病的染色体
Since Nowell (1960) found Ph ~ 1 chromosomes in patients with chronic myelogenous leukemia (CML), chromosome development of leukemia cells has progressed rapidly and chronic mycoplasma and chromosomes of other acute leukemias have been observed