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目的:探讨D-二聚体(D-dimer)与溃疡性结肠炎(UC)病情活动性是否存在相关性。方法:UC活动期患者127例作为研究对象,对照组53例,所有研究对象于治疗前及疗程结束后采静脉血3mL并分离血浆。以免疫比浊法检测血清D-dimer。结果:活动期UC患者血D-dimer明显高于对照组。抗凝治疗组经治疗后临床活动性评分优于未经抗凝治疗组,经抗凝治疗后患者D-dimer明显低于未经抗凝治疗组。结论:D-dimer血浆浓度与活动性UC患者的病情分级呈正相关。活动性UC患者处于明显的血栓前状态,适量应用低分子肝素以改善患者血液高凝状态对活动性溃疡性结肠炎治疗有效。
Objective: To investigate whether there is a correlation between D-dimer and ulcerative colitis (UC). Methods: A total of 127 patients with active UC were enrolled in this study. The control group consisted of 53 patients. All subjects received venous blood 3 mL and plasma before and after treatment. Serum D-dimer was detected by immunoturbidimetry. Results: D-dimer in active UC patients was significantly higher than that in control subjects. After anticoagulant therapy group clinical activity score was better than without anticoagulant therapy group after anticoagulant therapy in patients with D-dimer was significantly lower than without anticoagulant therapy group. Conclusion: The plasma concentration of D-dimer is positively correlated with the grading of patients with active UC. Active UC patients in obvious prethrombotic state, the amount of application of low molecular weight heparin to improve blood hypercoagulability in patients with active ulcerative colitis treatment.