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本文报道在固-液相转移催化的温和条件下2-烷基-2-(芳磺酰基)乙酸酯(1)与x,β-不饱和酯、腈、酮(2)的高选择性和高效率共轭加成反应,成功地合成了2,2-二取代戊二酸二酯(3a～d)、4-氰基丁酸酯(3e～g)和5-氧代己酸酯(3h～j),对它们的结构作了表征,初步讨论了本合成法的特点、Michael受体、相转移催化剂和溶剂等对共轭加成反应的影响。
This paper reports the high selectivity of 2-alkyl-2- (arylsulfonyl) acetate (1) to x, β-unsaturated esters, nitriles and ketones (2) under mild conditions of solid-liquid phase transfer catalysis (3a ~ d), 4-cyanobutyrate (3e ~ g) and 5-oxohexanoate have been successfully synthesized by high efficiency conjugation addition reaction (3h ~ j). Their structures were characterized. The characteristics of the synthesis method, the effects of Michael acceptor, phase transfer catalyst and solvent on the conjugate addition reaction were discussed.