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从多形炭角菌Xylaria polymorpha(Pers.:Fr.)Grer菌丝发酵产物乙酸乙酯部分中分离鉴定了21个化合物,包括2个新的drimane型倍半萜polymorphines A,B(1~2),1个新的phenyloxolane类化合物2-甲基-2-(4-羟甲基苯基)氧杂环戊烷(3)和18个已知化合物4~21.利用NMR和X射线单晶衍射技术对上述化合物结构进行鉴定与确认.化合物2具有一定的乙酰胆碱酯酶及α-葡萄糖苷酶抑制活性.此外,化合物3具有中等的全齿复活线虫Panagrellus redivivus抑制活性,在浓度为2.5 mg/m L时,线虫致死率为59.6%.
Twenty-one compounds were identified from the ethyl acetate fraction of mycelium fermentation product of Xylaria polymorpha (Pers.:Fr.) Grer, including two new drimane-type sesquiterpenoid polymorphines A and B (1-2 ), 1 new phenyloxolane compound 2-methyl-2- (4-hydroxymethylphenyl) oxolane (3) and 18 known compounds 4 to 21. The use of NMR and X-ray single crystals The results showed that Compound 2 had certain inhibitory activity of acetylcholinesterase and α-glucosidase.In addition, Compound 3 had medium inhibitory activity against Panagrellus redivivus, and at a concentration of 2.5 mg / The lethality of nematodes was 59.6% at m L.