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氧化型低密度脂蛋白在致动脉粥样硬化中起着重要的作用。但是,迄今尚未阐明冠心病患者血浆脂蛋白的氧化状态。本文比较了严重冠心病患者中氧化型脂蛋白的检出率是否高于健康受试者,同时观察在冠心病患者那一种脂蛋白成份(载脂蛋白,胆固醇,脂肪酸链)对氧化变异更为敏感。方法患者组(A组)和对照组(B组)各为23例。A组21例男性,2例女性,年龄60±1.8岁;B组 16例男性,7例女性,年龄48.4±1.9岁。二组均测定低密度脂蛋白(LDL)、极低密度脂蛋白(VLDL)和胆固醇(ch)。应用高效液相色谱法(HPLC)在LDL和VLDL中检测各种氧化型ch含量。采
Oxidized low-density lipoproteins play an important role in atherosclerosis. However, the oxidative status of plasma lipoproteins in patients with coronary heart disease has not yet been elucidated. This article compares the detection rate of oxidized lipoproteins in patients with severe coronary heart disease is higher than healthy subjects, and at the same time observed in patients with coronary heart disease that a lipoprotein composition (apolipoprotein, cholesterol, fatty acid chain) on the oxidative mutation more Sensitive. Methods Patients (group A) and control group (group B) were 23 cases each. A group of 21 males and 2 females, aged 60 ± 1.8 years; B group of 16 males and 7 females, aged 48.4 ± 1.9 years. Low density lipoprotein (LDL), very low density lipoprotein (VLDL) and cholesterol (ch) were measured in both groups. Various oxidized chions were detected in both LDL and VLDL using high performance liquid chromatography (HPLC). Mining