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探讨７２例确诊呼吸道合胞病毒（ＲＳＶ）特异性血清抗体及鼻咽分泌物脱落细胞中ＲＳＶ抗原阳性患儿急性期及恢复期Ｔ淋巴细胞亚群，血清ＩｇＧ、ＩｓＭ、ＩｇＡ及ＩＬ－２Ｒ的活性表达，动态观察了呼吸道合胞病毒感染患儿急性期、恢复期和正常对照组外周血淋巴细胞经ＰＨＡ刺激后，于不同时间（２４ｈ、４８ｈ、７２ｈ）细胞膜上ＩＬ－２Ｒ的活性表达。结果表明，抗体效价恢复期较急性期升高４～１２８倍，病例组急性期ＣＤ３、ＣＤ１６、Ｂ细胞升高，ＣＤ４／ＣＤ８的比值下降，ＩｇＧ、ＩｇＡ均降低，而ＩＬ－２Ｒ的活性表达呈下降趋势。此结果有助于探讨ＲＳＶ感染患儿的免疫紊乱发生机制。
To investigate the expression of IgG, IsM, IgA and IL-2R in 72 patients with RSV-specific serum and nasopharyngeal secretions exfoliated cells in acute and convalescent T lymphocyte subsets, RSV antigen-positive children The expression of IL-2R on the cell membrane was measured dynamically at different time (24h, 48h, 72h) after stimulation of PHA by peripheral blood lymphocytes of children with respiratory syncytial virus infection in acute, convalescent and normal control groups. The results showed that the recovery period of antibody titer was 4 ~ 128 times higher than that in acute phase. The cases of acute phase CD3, CD16, B cells increased, CD4 / CD8 ratio decreased, IgG, IgA decreased, while IL-2R activity Expression showed a downward trend. This result is helpful to investigate the mechanism of immune disorder in children with RSV infection.