多囊卵巢综合征(PCOS)是生育年龄妇女常见的生殖内分泌疾病。由于胰岛素抵抗在其发病中起重要作用,胰岛素增敏剂二甲双胍被用于PCOS的治疗。随着临床的广泛应用,对其作用机理和临床效果有了更深入的认识。二甲双胍可以恢复规律月经,改善多毛,降低体质量,促进排卵,改善妊娠结局,改善子宫内膜的胰岛素抵抗,避免远期并发症,特别是对青春期PCOS患者有较好的疗效。不同剂量的二甲双胍具有不同的治疗作用。对二甲双胍在治疗PCOS中的新进展做综述。 Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease in women of childbearing age. Since insulin resistance plays an important role in its pathogenesis, metformin, an insulin sensitizer, is used in the treatment of PCOS. With the wide application of clinical, its mechanism of action and clinical effects have a deeper understanding. Metformin can restore regular menstruation, improve hair, reduce body weight, promote ovulation, improve pregnancy outcomes, improve endometrial insulin resistance and avoid long-term complications, especially for puberty PCOS patients have a good effect. Different doses of metformin have different therapeutic effects. Review on the new progress of metformin in the treatment of PCOS.