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为了研究胃安素对实验性大鼠慢性萎缩性胃炎及胃癌前病变的防治作用，以光镜、电镜下胃粘膜病理形态学变化及有关生化项目为观察指标，结果发现胃安素预防组及治疗组发生萎缩性胃炎、肠化和不典型增生者较模型组明显减少（ Ｐ＜０． ０５），胃粘膜前列腺素 Ｅ，、已糖胺、血清皮质醇含量较模型组明显升高（ Ｐ ＜０．０５）；模型恢复组血清Ｄ－木糖水平显著低于正常组，胃液 ｐＨ值明显高于正常组（ Ｐ ＜０． ０５）。表明胃安素对实验性大鼠慢性胃炎脾虚证有较好的预防和治疗效果。
In order to study the prevention and treatment of gastric vasopressin on experimental chronic atrophic gastritis and gastric precancerous lesions, the gastric mucosal pathological changes and related biochemical items under light microscope and electron microscopy were used as observation indexes. The atrophic gastritis, intestinal metaplasia, and atypical hyperplasia were significantly decreased in the treatment group compared with the model group (P<0.05), and the gastric mucosal prostaglandin E, ketamine, and serum cortisol levels were significantly higher than those in the model group (P <0.05); The serum D-xylose level in the model recovery group was significantly lower than that in the normal group, and the gastric juice pH value was significantly higher than that in the normal group (P < 0.05). It is shown that the effect of pyelonerin on experimental chronic gastritis and spleen deficiency syndrome has better preventive and therapeutic effects.