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普罗帕酮(propafenone,用其盐酸盐)是较安全的抗心律失常药物,一天给药3次,可有效地抑制室性早搏。普罗帕酮为强效局部麻醉性膜稳定剂,主要作用为阻滞钠离子流入心肌细胞,从而减慢动作电位的升高。它与普鲁卡因胺等又有不同,因为它不延长恢复机化延续时间,因而是
Propafenone (used as its hydrochloride salt) is a safer antiarrhythmic drug administered 3 times a day and is effective in suppressing premature ventricular contractions. Propafenone is a potent local anesthetic membrane stabilizer that blocks sodium influx into cardiomyocytes and slows the rise of action potential. It is different from procainamide because it does not prolong the recovery time and is therefore