目的:探讨西宁地区应用高压氧(HBO)综合治疗新生儿缺氧缺血性脑病(HIE)的治疗效果。方法:治疗组53例,常规三项对症三项支持治疗基础上,加用高压氧治疗。对照组48例,给常规三项对症三项支持治疗,对治疗前后分别用NBNA评分。结果:治疗后对照组轻、中、重度HIE患儿NBNA评分分别为(38.65±0.64,32.68±0.76,30.38±1.10),治疗组分别为(38.11±0.73,37.88±0.82,35.48±0.79),轻度差别无显著性,中、重度差别有显著性。结论:西宁地区窒息率高,高压氧辅助治疗HIE疗效显著。 Objective: To investigate the therapeutic effect of HBO on neonates with hypoxic-ischemic encephalopathy (HIE) in Xining area. Methods: The treatment group of 53 cases, the conventional three symptomatic three supportive treatment based on the addition of hyperbaric oxygen therapy. The control group, 48 cases, to the conventional three symptomatic three supportive treatment, respectively, before and after treatment with NBNA score. Results: After treatment, the NBNA scores of the mild, moderate and severe HIE children were (38.65 ± 0.64,32.68 ± 0.76) and 30.38 ± 1.10 (38.11 ± 0.73, 37.88 ± 0.82, 35.48 ± 0.79, No significant difference between mild, moderate and severe differences were significant. Conclusion: Xining high asphyxia, hyperbaric oxygen therapy for the treatment of HIE significant effect.