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高热具有选择性的抑癌效应。一般来说,正常细胞能较长时间耐受42°～43℃,而肿瘤细胞在41.5°～42℃即失活。但不同肿瘤的细胞对超体温高热的敏感性也不相同,如有人报道,在癌瘤的全身热疗中,胃肠道肿瘤和肉瘤疗效较好,肺癌和黑色素瘤有部分效果,而乳癌和泌尿生殖系统肿瘤效果最差。因此了解对高温敏感度不同的癌细胞的生化反应特点和热疗效果关系,既可进一步阐明热疗疗效机理,又可为临床制订治疗方案提供依据。
High fever has a selective anti-cancer effect. In general, normal cells can tolerate 42°-43°C for a longer period of time, whereas tumor cells are inactivated at 41.5°-42°C. However, the sensitivity of cells of different tumors to hyperthermia is not the same. As reported, in the whole body hyperthermia of cancer, gastrointestinal tumors and sarcomas have good efficacy, lung cancer and melanoma have partial effects, and breast cancer The urogenital tumor is the worst. Therefore, understanding the relationship between the characteristics of biochemical reactions and the effects of hyperthermia in cancer cells with different sensitivity to high temperature can not only further clarify the therapeutic mechanism of hyperthermia, but also provide a basis for the clinical development of treatment plans.