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目的比较氯沙坦(LS)与苯那普利(BE)对高血压患者胰岛素敏感性与代谢的影响。方法测定116例高血压患者和48例正常者的胰岛素敏感性指数(ISI)与血脂等水平,根据ISI值分为LS治疗组与BE治疗组,治疗12周后再测定ISI和血脂等变化。结果两药治疗后,可见LS有明显促尿酸排泄作用(P<0.05),而对其他代谢指标则无明显影响(P>0.05)。结论LS和BE均可明显改善MH患者胰岛素敏感性,两药短期治疗,对其他代谢指标无明显不利影响。
Objective To compare the effects of losartan (LS) and benazepril (BE) on insulin sensitivity and metabolism in hypertensive patients. Methods Serum insulin and insulin sensitivity index (ISI) and serum lipids were determined in 116 patients with hypertension and 48 normal controls. The patients were divided into LS group and BE group according to ISI value. ISI and blood lipid levels were measured after 12 weeks of treatment. Results After the two drugs were treated, LS showed significant uric acid excretion (P <0.05), while no significant effect on other metabolic parameters (P> 0.05). Conclusion Both LS and BE can significantly improve insulin sensitivity in patients with MH. Short-term treatment with two drugs has no obvious adverse effect on other metabolic parameters.